Biochemical reactions in the cell occurs in a heterogeneous crowded environment, with approximately 30% of the cell volume occupied by macromolecules. Apparently, such a dense media is supposed to hinder the diffusion of biomolecules.

Recent experiments, however, suggest the opposite and the crowders are indeed found to facilitate various enzymatic activity of proteins, the target search process of proteins on DNA. Also their role in determining the thermodynamics and kietics of other biomolecular association is significant. Clearly, the detailed action of macromolecular crowders can not be described merely through the excluded volume interactions, rather factors originating from a high concentration of inert crowders should also be taken into account. 

We are interested in building computational models mimicking cellular environment and utilize advanced simulation method to calculate the consequences of this crowded environment on the behavior of proteins such as folding stability and kinetics, protein-protein and protein-nucleic acid interactions.