The complicated cellular mechanism is an outcome of dynamics and interactions of biomolecules such as proteins and nucleic acids. The physical properties of these molecules, which are key to their biological function, are often described by their energy landscape. We are focused on advancing our understanding of biomolecules (the sequence-structure-function problem) using a battery of computational and theoretical methods that capture their chemical and physical nature as well as the billions of years of evolutional design. Our goal is to decipher the complexity of proteins and nucleic acids that results in self-recognition and cellular communication and therefore a biological function.